Electronic Products & Technology

Smart fabrics with bioactive inks monitor body

Bioactive inks printed on wearable textiles can map conditions over the entire surface of the body

June 18, 2020  EP&T Magazine

Researchers at Tufts University’s School of Engineering in Medford MA, have developed biomaterial-based inks that respond to and quantify chemicals released from the body (e.g. in sweat and potentially other biofluids) or in the surrounding environment by changing colour. The inks can be screen printed onto textiles such as clothes, shoes, or even face masks in complex patterns and at high resolution, providing a detailed map of human response or exposure. The advance in wearable sensing, reported in Advanced Materials, could simultaneously detect and quantify a wide range of biological conditions, molecules and, possibly, pathogens over the surface of the body using conventional garments and uniforms. 

A T-shirt screen printed with pH sensitive bio-active inks can provide a map of pH response on the wearer. Variations of bio-active inks can detect other molecules released by the body, or in the surrounding environment

“The use of novel bioactive inks with the very common method of screen printing opens up promising opportunities for the mass-production of soft, wearable fabrics with large numbers of sensors that could be applied to detect a range of conditions,” said Fiorenzo Omenetto, corresponding author and the Frank C. Doble Professor of Engineering at Tufts’ School of Engineering. “The fabrics can end up in uniforms for the workplace, sports clothing, or even on furniture and architectural structures.”

Wearable patches and wristbands 

Wearable sensing devices have attracted considerable interest in monitoring human performance and health. Many such devices have been invented incorporating electronics in wearable patches, wristbands, and other configurations that monitor either localized or overall physiological information such as heart rate or blood glucose. The research presented by the Tufts team takes a different, complementary approach – non-electronic, colorimetric detection of a theoretically very large number of analytes using sensing garments that can be distributed to cover very large areas: anything from a patch to the entire body, and beyond.

The components that make the sensing garments possible are biologically activated silk-based inks. The soluble silk substrate in these ink formulations can be modified by embedding various “reporter” molecules – such as pH sensitive indicators, or enzymes like lactate oxidase to indicate levels of lactate in sweat. The former could be an indicator of skin health or dehydration, while the latter could indicate levels of fatigue of the wearer. Many other derivatives of the inks can be created due to the versatility of the silk fibroin protein by modifying it with active molecules such as chemically sensitive dyes, enzymes, antibodies and more. While the reporter molecules could be unstable on their own, they can become shelf-stable when embedded within the silk fibroin in the ink formulation.

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Screen printable bio-inks

The inks are formulated for screen printing applications by combining with a thickener (sodium alginate) and a plasticizer (glycerol). The screen printable bio-inks can be used like any ink developed for screen printing, and so can be applied not just to clothing but also to various surfaces such as wood, plastics and paper to generate patterns ranging from hundreds of microns to tens of meters. While the changes in colour presented by the inks can provide a visual cue to the presence or absence of an analyte, use of camera imaging analysis scanning the garments or other material can gather more precise information on both quantity and high resolution, sub-millimeter mapping.

The technology builds upon earlier work by the same researchers developing bioactive silk inks formulated for inkjet-printing to create petri dishes, paper sensors, and laboratory gloves that can indicate bacterial contamination by changing colours.

“The screen printing approach provides the equivalent of having a large, multiplexed arrangement of sensors covering extensive areas of the body, if worn as a garment, or even on large surfaces such as room interiors,” said Giusy Matzeu, research assistant professor of biomedical engineering at Tufts School of Engineering and first author of the paper. “Coupled with image analysis, we can obtain a high resolution map of colour reactions over a large area and gain more insight on overall physiological or environmental state. In theory, we could extend this method to track air quality, or support environmental monitoring for epidemiology.”


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